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Journal Watch condenses summaries of key research across specialties from more than 250 medical journals into concise yet comprehensive articles, incorporating clinical commentary from prominent physician-editors in the field.
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Featured Article
SUMMARY AND COMMENT
Antiepileptic Drug Comparison: More Details
- May 15, 2012
- Robert C. Knowlton, MD, MSPH
A post hoc analysis of the focal epilepsy arm in the SANAD trial reveals outcome predictors for patients receiving specific AED treatments.
- Reviewing:
- Bonnett L et al. Lancet Neurol 2012 Apr; 4:331
Recent Neurology Articles
SUMMARY AND COMMENT
Lasmiditan for Acute Migraine Treatment
- May 15, 2012
- Denise E. Chou, MD
Oral lasmiditan, a novel 5-HT1F receptor agonist, appears to be a safe and effective acute migraine therapy without the vasoactive adverse effects of triptans.
- Reviewing:
- Färkkilä M et al. Lancet Neurol 2012 May; 11:405
SUMMARY AND COMMENT
Is Botulinum Toxin Type A Effective for Headache Prophylaxis?
- May 15, 2012
- Peter J. Goadsby, MD, PhD, DSc
A meta-analysis finds that it may be effective for chronic, but not episodic, migraine headache but not for any form of tension-type headache.
- Reviewing:
- Jackson JL et al. JAMA 2012 Apr 25; 307:1736
CORRECTION
Correction: Antidepressants for Patients with Parkinson DiseaseFree
- May 2, 2012
- The Editors
- Psychiatry
A correction to a summary published April 30, 2012
SUMMARY AND COMMENT
Antipsychotics and Myocardial Infarction in Dementia Patients
- May 1, 2012
- Brandy R. Matthews, MD
The risk for MI was significantly elevated in the first month after initiation of antipsychotics in dementia patients already treated with cholinesterase inhibitors.
- Reviewing:
- Pariente A et al. Arch Intern Med 2012 Apr 23; 172:648
SUMMARY AND COMMENT
Physical Activity in Elders and Alzheimer Risk
- May 1, 2012
- Brandy R. Matthews, MD
An actigraphy study supports the role of activity in preventing AD.
- Reviewing:
- Buchman AS et al. Neurology 2012 Apr 24; 78:1323
CASE HISTORY
Stabbing Headache and Ptosis: Case Diagnosis
- May 1, 2012
- Jaime Toro, MD, Juan Pablo Fernandez MD, and Camilo Diaz MD
The case diagnosis and a discussion
SUMMARY AND COMMENT
Reducing Seizures Caused by AVMs
- May 1, 2012
- Seemant Chaturvedi, MD
Radiosurgery reduced long-term seizure frequency in a retrospective study.
- Reviewing:
- Yang S-Y et al. Neurology 2012 Apr 24; 78:1292
SUMMARY AND COMMENT
Identifying Candidates for Organ Donation after Cardiac Death
- May 1, 2012
- Hooman Kamel, MD
Assessment of brainstem function can identify patients who will develop cardiac arrest soon enough after withdrawal of life support for organs to be salvaged.
- Reviewing:
- Rabinstein AA et al. Lancet Neurol 2012 May; 11:414
SUMMARY AND COMMENT
Judicious Pacing for Myotonic Dystrophy
- May 1, 2012
- Michael Benatar, MD, MS, PhD
In a large retrospective study, DM1 patients with conduction abnormalities had lower all-cause mortality and sudden death with electrophysiological testing and prophylactic pacing than with a noninvasive strategy.
- Reviewing:
- Wahbi K et al. JAMA 2012 Mar 28; 307:1292
SUMMARY AND COMMENT
Antidepressants for Patients with Parkinson DiseaseFree
- April 30, 2012
- Jonathan Silver, MD
- Psychiatry
A well-controlled, multicenter study suggests efficacy of paroxetine and venlafaxine.
- Reviewing:
- Richard IH et al. Neurology 2012 Apr 17; 78:1229
Editor's Picks from across Journal Watch
SUMMARY AND COMMENT
Headaches Are Common in Children with Tourette Syndrome
- April 25, 2012
- By F. Bruder Stapleton, MD
- Pediatrics and Adolescent Medicine
At Cleveland Clinic, 17% of children with TS reported having a migraine headache during the previous 6 months.
- Reviewing:
- J Pediatr 2012 Mar 15
SUMMARY AND COMMENT
First Complex Febrile Seizure Portends Low Risk for Intracranial Pathology
- April 13, 2012
- By Katherine Bakes, MD
- Emergency Medicine
Fewer than 1% of children with first complex febrile seizure and a normal neurological examination have clinically important intracranial pathology.
- Reviewing:
- Pediatr Emerg Care 2012 Apr; 28:316
SUMMARY AND COMMENT
Isolated Severe Injury Mechanism Predicts Low Risk for Pediatric Intracranial Injury
- April 13, 2012
- By Katherine Bakes, MD
- Emergency Medicine
Children with severe injury mechanism as the only one of the six risk factors included in the PECARN head injury prediction rule were at very low risk for clinically important traumatic brain injury.
- Reviewing:
- Arch Pediatr Adolesc Med 2012 Apr; 166:356
SUMMARY AND COMMENT
In Alzheimer Disease, Antioxidants Hurt
- April 23, 2012
- By Jonathan Silver, MD
- Psychiatry
Antioxidants do not improve AD biomarkers and adversely affect cognition.
- Reviewing:
- Arch Neurol 2012 Mar 19
Journal Watch Neurology summarizes important medical journal articles about a wide variety of neurologic subjects including Alzheimer disease, autoimmune disease, epilepsy, headache, movement disorders, multiple sclerosis, neuropathy, Parkinson disease, sleep, and stroke.
