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Journal Watch condenses summaries of key research across specialties from more than 250 medical journals into concise yet comprehensive articles, incorporating clinical commentary from prominent physician-editors in the field.
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Featured Article
SUMMARY AND COMMENT
Intravenous Thrombolysis for Acute Ischemic Stroke with Prior Stroke and Diabetes: Think Different?Free
- January 24, 2012
- Clotilde Balucani, MD, and Steven R. Levine, MD
Diabetes and prior stroke should not preclude use of IV thrombolysis for stroke.
- Reviewing:
- Mishra NK et al. Neurology 2011 Nov 22; 77:1866
Recent Neurology Articles
SUMMARY AND COMMENT
Are We Getting Closer to Blood Tests for Parkinson Disease?
- January 24, 2012
- Michael S. Okun, MD
A pilot study suggests so, despite methodologic issues.
- Reviewing:
- Foulds PG et al. FASEB J 2011 Dec; 25:4127
NEWS IN CONTEXT
FDA Approves Hand-Held Device to Spot Intracranial Hematomas
- January 24, 2012
- Hooman Kamel, MD
A new bedside device has potential for streamlining the care of patients with suspected intracranial bleeding, but widespread use should await further data.
SUMMARY AND COMMENT
Gene for Vitamin D Metabolism Implicated in Multiple SclerosisFree
- January 17, 2012
- Robert T. Naismith, MD
Mutations that lead to altered vitamin D activation are identified as rare variants in familial MS.
- Reviewing:
- Ramagopalan SV et al. Ann Neurol 2011 Dec; 70:881
CORRECTION
Correction: Update on AAN Guidelines for Treatment of Essential TremorFree
- January 17, 2012
- The Editors
A correction to a clinical practice guideline watch published January 3, 2012
SUMMARY AND COMMENT
Increased Cancer Risk Among Patients with Myotonic Muscular DystrophyFree
- January 10, 2012
- Michael Benatar, MD, MS, PhD
Population-based data from Swedish and Danish national registries allowed for the first quantitative assessment of cancer risk in these patients.
- Reviewing:
- Gadalla SM et al. JAMA 2011 Dec 14; 306:2480
SUMMARY AND COMMENT
Complications from Rebleeding in Aneurysmal Subarachnoid Hemorrhage
- January 10, 2012
- Alejandro A. Rabinstein, MD
After SAH, rebleeding increases mortality and the risk for cerebral and systemic complications but does not change the course or severity of delayed cerebral ischemia.
- Reviewing:
- Lord AS et al. Neurology 2012 Jan 3; 78:31
SUMMARY AND COMMENT
DWI-FLAIR Mismatch to Identify Acute Ischemic Stroke: Promising Data
- January 10, 2012
- Chelsea S. Kidwell, MD
A multicenter study suggests that the presence of mismatch between diffusion-weighted and fluid-attenuated inversion-recovery images may be a useful surrogate marker for ischemic stroke presentation within the time window for treatment with intravenous thrombolysis.
- Reviewing:
- Thomalla G et al. Lancet Neurol 2011 Nov; 10:978
SUMMARY AND COMMENT
Computerized Neurocognitive Testing in U.S. High Schools
- January 10, 2012
- Jeffrey Kutcher, MD
Researchers report the prevalence of computerized neurocognitive testing in a subset of schools but do not provide useful data on clinical outcomes.
- Reviewing:
- Meehan WP III et al. Pediatrics 2012 Jan; 129:38
SUMMARY AND COMMENT
A Potential Imaging Biomarker of Sports-Related Concussion
- January 10, 2012
- Jeffrey Kutcher, MD
Researchers present preliminary work on the use of magnetic resonance phase-contrast angiography, a potentially groundbreaking biomarker of concussion.
- Reviewing:
- Maugans TA et al. Pediatrics 2012 Jan; 129:28
SUMMARY AND COMMENT
MRI Before Epidural Steroid Injections?
- January 10, 2012
- Jaime Toro, MD
In patients with lumbosacral radiculopathy, MRI might not affect outcomes substantially, but it can aid planning of injections.
- Reviewing:
- Cohen SP et al. Arch Intern Med 2011 Dec 12
Editor's Picks from across Journal Watch
SUMMARY AND COMMENT
Early Seizures After Stroke Are Common
- January 5, 2012
- By Allan S. Brett, MD
- General Medicine
Frequencies were about 4% and 15% within 7 days after ischemic and hemorrhagic strokes, respectively.
- Reviewing:
- Neurology 2011 Nov 15; 77:1785
SUMMARY AND COMMENT
Are Diabetes Mellitus and Epilepsy Linked in Children?
- December 14, 2011
- By F. Bruder Stapleton, MD
- Pediatrics and Adolescent Medicine
Children with type 1 diabetes mellitus have much higher risk for epilepsy than children in the general population.
- Reviewing:
- J Pediatr 2011 Nov 7
SUMMARY AND COMMENT
Autistic Children Have More Neurons
- December 5, 2011
- By Barbara Geller, MD
- Psychiatry
These findings support the hypothesis that autism is present at birth, even if not yet clinically evident. CME
- Reviewing:
- JAMA 2011 Nov 9; 306:2001
SUMMARY AND COMMENT
Testing the Causative Criteria for Cerebral Palsy
- November 3, 2011
- By Diane J. Angelini, EdD, CNM, FACNM, FAAN, NEA-BC
- Women's Health
Most neonates with cerebral palsy who had experienced fetal heart rate deterioration had clinical characteristics consistent with task force criteria.
- Reviewing:
- Obstet Gynecol 2011 Oct; 118:824
Journal Watch Neurology summarizes important medical journal articles about a wide variety of neurologic subjects including Alzheimer disease, autoimmune disease, epilepsy, headache, movement disorders, multiple sclerosis, neuropathy, Parkinson disease, sleep, and stroke.
