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Search for Alzheimer's Disease in Neurology
Physician-authored summaries on the latest research on Alzheimer's disease, editorials on Alzheimer's disease, and perspectives on Alzheimer's disease - drawn from the top medical journals.
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You searched for: Alzheimer's disease in Neurology
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Timing of Biomarker Changes in Alzheimer Disease Process
- February 14, 2012
- Jennifer Rose V. Molano, MD
- Neurology
Abnormal amyloid biomarker levels may be seen before abnormal tau biomarker levels in patients progressing toward Alzheimer disease.- Reviewing:
- Jack CR Jr et al., Arch Neurol 2011 Dec; 68:1526.
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Intranasal Insulin Therapy for AD and Amnestic MCI
- December 6, 2011
- Martin R. Farlow, MD
- Neurology
A pilot study suggests a benefit in maintaining cognition in patients with mild cognitive impairment or Alzheimer disease.- Reviewing:
- Craft S et al., Arch Neurol 2011 Sep 12;:
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Predicting Conversion from Mild Cognitive Impairment to Alzheimer Disease
- October 4, 2011
- Brandy R. Matthews, MD
- Neurology
Cognitive and functional measures remain significant predictors of decline compared with other biomarkers.- Reviewing:
- Gomar JJ et al., Arch Gen Psychiatry 2011 Sep; 68:961.
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Nonmemory Symptoms Can Lead to Misdiagnosis in Early-Onset Alzheimer Disease Free
- June 14, 2011
- Brandy R. Matthews, MD
- Neurology
Initial and final diagnoses were incorrect in about half of patients with atypical presentations.- Reviewing:
- Balasa M et al., Neurology 2011 May 17; 76:1720.
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Memantine Is Not Effective for Mild Alzheimer Disease Free
- May 17, 2011
- Martin Rhys Farlow, MD
- Neurology
Off-label use of memantine for mild AD is not supported by the findings of a meta-analysis that focused specifically on patients with mild disease.- Reviewing:
- Schneider LS et al., Arch Neurol 2011 Apr 11;:
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Updated Diagnostic Criteria for All Stages of Alzheimer Disease
- May 17, 2011
- Brandy R. Matthews, MD
- Neurology
These criteria emphasize early and preclinical stages of AD and the usefulness of biomarkers.- Reviewing:
- Jack CR Jr et al., Alzheimers Dement 2011 May; 7:257. Sperling RA et al., Alzheimers Dement 2011 May; 7:280. McKhann GM et al., Alzheimers Dement 2011 May; 7:263. Albert MS et al., Alzheimers Dement 2011 May; 7:270.
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New Genes Associated with Alzheimer Disease
- May 10, 2011
- Brandy R. Matthews, MD
- Neurology
Two large genome-wide association studies revealed at least four new susceptibility loci for AD.- Reviewing:
- Naj AC et al., Nat Genet 2011 May; 43:436. Hollingworth P et al., Nat Genet 2011 May; 43:429.
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Clusterin and Alzheimer Disease Free
- April 26, 2011
- Brandy R. Matthews, MD
- Neurology
Elevated plasma levels of the protein clusterin were associated with AD prevalence and severity, but they did not predict AD incidence or distinguish between AD and vascular dementia.- Reviewing:
- Schrijvers EMC et al., JAMA 2011 Apr 6; 305:1322.
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DHA Supplementation in Alzheimer Disease Free
- December 14, 2010
- Martha Clare Morris, ScD
- Neurology
A negative trial raises questions.- Reviewing:
- Quinn JF et al., JAMA 2010 Nov 3; 304:1903.
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Dementia Associated with Heavy Smoking in Midlife Free
- November 16, 2010
- Brandy R. Matthews, MD
- Neurology
Midlife cigarette smoking of two packs per day or more portends an elevated risk for overall dementia, Alzheimer disease, and vascular dementia in later life.- Reviewing:
- Rusanen M et al., Arch Intern Med 2010 Oct 25;:
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Biologically Active Vitamin B12, Homocysteine, and Alzheimer Disease Free
- November 9, 2010
- Brandy R. Matthews, MD
- Neurology
Baseline serum levels of homocysteine correlated positively and holotranscobalamin levels correlated negatively with AD risk in a population-based, 7-year cohort study.- Reviewing:
- Hooshmand B et al., Neurology 2010 Oct 19; 75:1408.
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Redefining Alzheimer Disease Free
- November 2, 2010
- Brandy R. Matthews, MD
- Neurology
An ad hoc international working group proposes a new lexicon, to be used in both clinical and research settings, that defines AD on a continuum.- Reviewing:
- Dubois B et al., Lancet Neurol 2010 Nov; 9:1118.
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Diagnosis-Independent Cerebrospinal Fluid Biomarkers of Alzheimer Disease
- November 2, 2010
- Gad A. Marshall, MD
- Neurology
A CSF signature accurately classified people with and without Alzheimer disease.- Reviewing:
- De Meyer G et al., Arch Neurol 2010 Aug; 67:949.
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More Clues in the Alzheimer Conundrum
- March 9, 2010
- David A. Drachman, MD
- Neurology
Two studies alter our thinking about the cause(s) and treatment(s) for Alzheimer disease.- Reviewing:
- Green RC et al., JAMA 2009 Dec 16; 302:2557. Lieb W et al., JAMA 2009 Dec 16; 302:2565.
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Mediterranean Diet, Physical Activity, Cognitive Function, and Dementia Risk
- December 1, 2009
- Gad A. Marshall, MD
- Neurology
Two new studies addressed whether diet and physical activity in elders affect cognitive decline and dementia.- Reviewing:
- Scarmeas N et al., JAMA 2009 Aug 12; 302:627. Féart C et al., JAMA 2009 Aug 12; 302:638. Knopman DS., JAMA 2009 Aug 12; 302:686.
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CSF Biomarkers and AD Prediction
- September 15, 2009
- David Knopman, MD
- Neurology
In patients with mild cognitive impairment, CSF biomarkers helped predict who would develop Alzheimer disease.- Reviewing:
- Mattsson N et al., JAMA 2009 Jul 22/29; 302:385. Petersen RC and Trojanowski JQ., JAMA 2009 Jul 22/29; 302:436.
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Can Patients Test Their Own Memory?
- September 8, 2009
- Paul R. Solomon, PhD
- Neurology
Can the TYM (test your memory) serve as a self-administered screening test?- Reviewing:
- Brown J et al., BMJ 2009 Jun 9; 338:b2030.
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Alzheimer Disease and Inflammation: More Epidemiology, More Questions
- August 4, 2009
- Joseph Rogers, PhD
- Neurology
For anti-inflammatory approaches to Alzheimer disease, timing may be everything.- Reviewing:
- Breitner JCS et al., Neurology 2009 Jun 2; 72:1899. Bennett DA and Whitmer RA., Neurology 2009 Jun 2; 72:1884.
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Free Copper and Alzheimer Disease
- April 28, 2009
- Neeraj Kumar, MD
- Neurology
More evidence associates free copper with cognitive decline, but a causative role for copper remains to be established.- Reviewing:
- Squitti R et al., Neurology 2009 Jan 6; 72:50.
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Driving with Dementia
- April 7, 2009
- Germaine L. Odenheimer, MD
- Neurology
Scores on cognitive tests relate to driving behaviors in people with Alzheimer disease.- Reviewing:
- Dawson JD et al., Neurology 2009 Feb 10; 72:521.
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