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Search for Alzheimer's Disease in Neurology
Physician-authored summaries on the latest research on Alzheimer's disease, editorials on Alzheimer's disease, and perspectives on Alzheimer's disease - drawn from the top medical journals.
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You searched for: Alzheimer's disease in Neurology
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CSF Biomarkers and AD Prediction
- September 15, 2009
- David Knopman, MD
- Neurology
In patients with mild cognitive impairment, CSF biomarkers helped predict who would develop Alzheimer disease.- Reviewing:
- Mattsson N et al., JAMA 2009 Jul 22/29; 302:385. Petersen RC and Trojanowski JQ., JAMA 2009 Jul 22/29; 302:436.
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Can Patients Test Their Own Memory?
- September 8, 2009
- Paul R. Solomon, PhD
- Neurology
Can the TYM (test your memory) serve as a self-administered screening test?- Reviewing:
- Brown J et al., BMJ 2009 Jun 9; 338:b2030.
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Alzheimer Disease and Inflammation: More Epidemiology, More Questions
- August 4, 2009
- Joseph Rogers, PhD
- Neurology
For anti-inflammatory approaches to Alzheimer disease, timing may be everything.- Reviewing:
- Breitner JCS et al., Neurology 2009 Jun 2; 72:1899. Bennett DA and Whitmer RA., Neurology 2009 Jun 2; 72:1884.
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Free Copper and Alzheimer Disease
- April 28, 2009
- Neeraj Kumar, MD
- Neurology
More evidence associates free copper with cognitive decline, but a causative role for copper remains to be established.- Reviewing:
- Squitti R et al., Neurology 2009 Jan 6; 72:50.
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Driving with Dementia
- April 7, 2009
- Germaine L. Odenheimer, MD
- Neurology
Scores on cognitive tests relate to driving behaviors in people with Alzheimer disease.- Reviewing:
- Dawson JD et al., Neurology 2009 Feb 10; 72:521.
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Statins and Risk for Alzheimer Disease
- March 17, 2009
- Gad A. Marshall, MD
- Neurology
In a large, prospective study, use of statin cholesterol-lowering drugs was associated with reduced risk for Alzheimer disease, independent of the drug’s lipophilicity.- Reviewing:
- Haag MDM et al., J Neurol Neurosurg Psychiatry 2009 Jan; 80:13. Sparks L., J Neurol Neurosurg Psychiatry 2009 Jan; 80:1.
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Do White-Matter Hyperintensities Reflect Disease Process or Underlying Susceptibility?
- September 9, 2008
- Françoise Gray, MD, PhD
- Neurology
A comparison of the spatial distribution of white-matter hyperintensities in subjects with Alzheimer disease, cerebral amyloid angiopathy, and healthy aging shows that the pattern is not disease-specific but reflects regional variability in normal cerebral perfusion.- Reviewing:
- Holland CM et al., Stroke 2008 Apr; 39:1127.
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Continued Support for Protective Effects of NSAIDs in Alzheimer Disease
- September 2, 2008
- Joseph Rogers, PhD
- Neurology
The largest epidemiologic survey to date of NSAIDs and prevention of Alzheimer disease suggests highly significant, duration-dependent effects of common NSAIDs.- Reviewing:
- Vlad SC et al., Neurology 2008 May 6; 70:1672.
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Serum Insulin in Nondiabetic Alzheimer Patients Correlates with Brain Volume and Cognition
- January 8, 2008
- Wesley Farris, MD
- Neurology
Contrary to expectations, increased peripheral insulin levels correlated with fewer AD markers.- Reviewing:
- Burns JM et al., Neurology 2007 Sep 11; 69:1094.
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Diet and Mortality in Alzheimer Disease
- December 11, 2007
- Joe Verghese, MD
- Neurology
As in other populations, people with AD who followed the Mediterranean diet had reduced mortality risk.- Reviewing:
- Scarmeas N et al., Neurology 2007 Sep 11; 69:1084. Galvin JE., Neurology 2007 Sep 11; 69:1072.
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Who Progresses from Mild Cognitive Impairment to Alzheimer Disease? Free
- August 7, 2007
- Warren J. Strittmatter, MD
- Neurology
Although these analyses shed light on variables that affect progression, the predictors are not accurate enough to be used for individual patients.- Reviewing:
- Fleisher AS et al., Neurology 2007 May 8; 68:1588-95. Palmer K et al., Neurology 2007 May 8; 68:1596-602. Kemppainen NM et al., Neurology 2007 May 8; 68:1603-6.
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Imaging Amyloid and Regional Cerebral Glucose Metabolism in Alzheimer Disease Free
- June 19, 2007
- Stephen Gomperts, MD, PhD
- Neurology
Amyloid imaging distinguishes AD from normal brain, but its clinical utility awaits further study.- Reviewing:
- Edison P et al., Neurology 2007 Feb 13; 68:501-8.
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Effects of Aging on Alzheimer Disease
- March 6, 2007
- David A. Wolk, MD
- Neurology
The author proposes that age-related factors make important contributions to the development of a neuronal milieu conducive to AD.- Reviewing:
- Drachman DA., Neurology 2006 Oct 24; 67:1340-52.
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Amyloid-β Binding Compound Looks Promising for Mild AD
- February 27, 2007
- Cynthia A. Lemere, PhD
- Neurology
3APS safely lowered CSF amyloid-beta-42 levels after 3 months in patients with mild-to-moderate AD.- Reviewing:
- Aisen PS et al., Neurology 2006 Nov 28; 67:1757-63.
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Differing Brain Activation in Familial AD: A Functional-MRI Study
- February 6, 2007
- Bradford C. Dickerson, MD
- Neurology
In a family with a presenilin mutation, brain activation was increased in a young carrier and decreased in a middle-aged carrier.- Reviewing:
- Mondadori CRA et al., Brain 2006 Nov; 129:2908-22.
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Alzheimer Disease plus Stroke Free
- January 16, 2007
- David A. Drachman, MD
- Neurology
The result of this combination exceeds the sum of its parts.- Reviewing:
- Gamaldo A et al., Neurology 2006 Oct 24; 67:1363-9. Regan C et al., Neurology 2006 Oct 24; 67:1357-62.
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Memantine for Behavior Problems in Alzheimer Disease Free
- November 21, 2006
- Andrew E. Budson, MD
- Neurology
Adding memantine to donepezil improves certain behavioral problems, though the reason remains unclear.- Reviewing:
- Cummings JL et al. for the Memantine MEM-MD-02 Study Group., Neurology 2006 Jul 11; 67:57-63.
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Amyloid Imaging in Alzheimer Disease
- October 31, 2006
- Keith A. Johnson, MD
- Neurology
Might imaging aid in AD diagnosis and treatment?- Reviewing:
- Archer HA et al., Ann Neurol 2006 Jul; 60:145-7.
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Differentiating Dementia with Lewy Bodies from Alzheimer Disease
- August 1, 2006
- James E. Galvin, MD, MPH
- Neurology
Assessment for deficits in visuospatial function may assist in the diagnosis.- Reviewing:
- Tiraboschi P et al., Brain 2006 Mar; 129:729-35.
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Can Secretase Inhibition Reverse Alzheimer Disease Pathology?
- July 6, 2006
- Michael S. Wolfe, PhD
- Neurology
Stopping amyloid-β production did not reduce Alzheimer-like plaques in mice.- Reviewing:
- Jankowsky JL et al., PLoS Med 2005 Dec; 2:e355.
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