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Alzheimer's Disease
Physician-authored summaries on the latest research on Alzheimer's disease, editorials on Alzheimer's disease, and perspectives on Alzheimer's disease - drawn from the top medical journals.
You searched for: Alzheimer's disease Items 1 to 20 of 153 results
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A New Direction for Treating Alzheimer Disease
- August 22, 2006
- John H. Growdon, MD
Selective M1 cholinergic agonists show promise as a novel approach to treating Alzheimer disease.- Covering:
- Caccamo A et al., Neuron 2006 Mar 2; 49:671-82.
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Insulin Administration Elevates Plasma A-β Levels and CSF Inflammatory Markers
- January 12, 2006
- R. Wesley Farris II, MD
Hyperinsulinemia, even in the absence of diabetes, is a known risk factor for Alzheimer disease (AD), but the reasons are not well understood. Insulin may . . .- Covering:
- Fishel MA et al., Arch Neurol 2005 Oct; 62:1539-44.
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Survival in FTD Decreased Compared to AD
- December 8, 2005
- Michael D. Greicius, MD, MPH
After Alzheimer disease (AD), frontotemporal dementia (FTD) is considered the second most common dementia occurring in people under age 65. As neurologists become more adept . . .- Covering:
- Rascovsky K et al., Neurology 2005 Aug 9; 65:397-403.
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Does Testosterone Supplementation Improve Cognitive Function in Men with AD or Mild Cognitive Impairment?
- October 6, 2005
- Andrew G. Herzog, MD, MSc
Hypogonadism may be a risk factor for the development of Alzheimer disease (AD), but investigations of the possible benefits of testosterone supplementation have yielded contradictory . . .- Covering:
- Cherrier MM et al., Neurology 2005 Jun 28; 64:2063-8.
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Qualitative Neuropsychological Measures Help Distinguish FTD from AD
- September 8, 2005
- Michael D. Greicius, MD, MPH
Anticipating the development of potent but potentially toxic treatments for Alzheimer disease (AD), experts are directing much attention toward improving diagnostic accuracy. Diagnostic aids can . . .- Covering:
- Thompson JC et al., J Neurol Neurosurg Psychiatry 2005 Jul; 76:920-7.
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Driving with Early AD
- June 23, 2005
- Germaine L. Odenheimer, MD
Is early Alzheimer disease (AD) associated with safety errors during driving, and can visual and cognitive measures predict these errors? To find out, researchers studied . . .- Covering:
- Uc EY et al., J Neurol Neurosurg Psychiatry 2005 Jun; 76:764-8.
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Education Is a Double-Edged Sword in AD
- January 14, 2005
- Aaron Nelson, PhD
Stern and colleagues at Columbia first reported that individuals with higher levels of education appeared to come to clinical diagnosis of Alzheimer disease (AD) later . . .- Covering:
- Wilson RS et al., Neurology 2004 Oct 12; 63:1198-202.
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Potential New Drug Target for Alzheimer Disease Prevention and Treatment
- October 10, 2003
- Matthew P. Frosch, MD, PhD
Because of the central role of amyloid-beta (Aβ) in the pathogenesis of Alzheimer disease (AD), much effort has been directed toward finding interventions that can . . .- Covering:
- Phiel CJ et al., Nature 2003 May 22; 423:435-9.
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No Benefit of (Some) NSAIDs in Alzheimer's Disease Progression
- September 5, 2003
- Thomas L. Schwenk, MD
Epidemiologic associations and results of clinical studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) might help prevent or slow the development of Alzheimer's disease (AD; Journal . . .- Covering:
- Aisen PS et al., JAMA 2003 Jun 4; 289:2819-26.
- Launer LJ., JAMA 2003 Jun 4; 289:2865-7.
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Galantamine Is Effective for Mild-to-Moderate Alzheimer's Disease
- November 9, 2001
- JL Cummings
Galantamine was recently approved by the FDA for the treatment of patients with mild-to-moderate Alzheimer's disease (AD). Galantamine becomes the fourth cholinesterase inhibitor (along with . . .- Covering:
- Olin J and Schneider L., In: The Cochrane Library. Issue 3, 2001;:
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- Olin J and Schneider L., In: The Cochrane Library. Issue 3, 2001;:
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Neural Processing of Novel Events Disrupted in Early Alzheimer's Disease
- August 23, 2001
- KM Heilman
Patients in the mild to moderate stages of Alzheimer's disease (AD) often seem apathetic and fail to attend to novel stimuli. In EEG studies of . . .- Covering:
- Daffner KR et al., Neurology 2001 May 22; 56:
1377 1383 .
- Daffner KR et al., Neurology 2001 May 22; 56:
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Dementia and Alzheimer's Disease: Does Incidence Differ Across the Globe?
- April 25, 2001
- PB Gorelick
In this cross-cultural prospective study, researchers compared incidence of dementia and Alzheimer's disease (AD) in two diverse, elderly (aged 65 or older), community-based populations without . . .- Covering:
- Hendrie HC et al., JAMA 2001 Feb 14; 285:
739 747 . - Farrer LA., JAMA 2001 Feb 14; 285:
796 798 .
- Hendrie HC et al., JAMA 2001 Feb 14; 285:
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Early-Adult Head Injury and Risk for Subsequent Alzheimer's Disease
- December 20, 2000
- R Mayeux
Despite numerous investigations, the relation between traumatic head injury and the development of Alzheimer's disease (AD) remains unclear (see, for example, JWN March 2000, p. . . .- Covering:
- Plassman BL et al., Neurology 2000 Oct; 55:
1158 1166 .
- Plassman BL et al., Neurology 2000 Oct; 55:
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Another Possible New Drug Target for Alzheimer's Disease
- November 2, 2000
- EH Koo
The prevailing hypothesis concerning Alzheimer's disease (AD) pathogenesis centers on the production of amyloid β-protein (Aβ). There has been a recent flurry of activity identifying . . .- Covering:
- Yu G et al., Nature 2000 Sep 7; 407:
48 54 .
- Yu G et al., Nature 2000 Sep 7; 407:
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Is Apolipoprotein(a) Associated with Alzheimer's Disease?
- June 1, 2000
- WJ Strittmatter
Although the association of the apolipoprotein E4 (APOE (epsilon)4) allele with increased risk of Alzheimer's disease (AD) was discovered 8 years ago, and although . . .- Covering:
- Mooser V et al., Ann Intern Med 2000 Apr 4; 132:
533 537 .
- Mooser V et al., Ann Intern Med 2000 Apr 4; 132:
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A New Drug Target for Alzheimer's Disease on the Horizon?
- March 1, 2000
- EH Koo
Alzheimer's disease is the most common age-associated neurodegenerative disorder, and yet the pathogenetic mechanisms remain unknown. What's more, effective treatments for this devastating disorder are . . .- Covering:
- Vassar R et al., Science 1999 Oct 22; 286:
735 741 . - Yan R et al., Nature 1999 Dec 2; 402:
533 537 . - Sinha S et al., Nature 1999 Dec 2; 402:
537 540 . - Hussain I et al., Mol Cell Neurosci 1999 Dec 14; 6:
419 427 .
- Vassar R et al., Science 1999 Oct 22; 286:
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New Treatments for Alzheimer's Disease Reviewed
- March 1, 2000
- RA Sperling
The past decade has seen a remarkable increase in the number of clinical trials of new pharmacologic agents for treating Alzheimer's disease'. These authors reviewed . . .- Covering:
- Mayeux R and Sano M., N Engl J Med 1999 Nov 25; 341:
1670 1679 .
- Mayeux R and Sano M., N Engl J Med 1999 Nov 25; 341:
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Lewy Body Variant of Alzheimer's Disease
- November 1, 1999
- JC Morris
Postmortem assessment of individuals with a premortem diagnosis of possible or probable Alzheimer's disease (AD) frequently shows coexistent non-AD neuropathology. Perhaps the most common comorbid . . .- Covering:
- Heyman A et al., Neurology 1999 Jun; 52:
1839 1844 .
- Heyman A et al., Neurology 1999 Jun; 52:
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Education Level Affects Dementia Diagnosis
- February 19, 2008
- Dorene M. Rentz, PsyD
Educational achievement is associated with both delay in dementia diagnosis and accelerated memory decline after diagnosis.- Covering:
- Hall CB et al., Neurology 2007 Oct 23; 69:1657.
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Serum Insulin in Nondiabetic Alzheimer Patients Correlates with Brain Volume and Cognition
- January 8, 2008
- Wesley Farris, MD
Contrary to expectations, increased peripheral insulin levels correlated with fewer AD markers.- Covering:
- Burns JM et al., Neurology 2007 Sep 11; 69:1094.
You searched for: Alzheimer's disease Items 1 to 20 of 153 results