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You searched for: Huntington's disease in Neurology
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A New Treatment for Huntington Disease?
- December 6, 2011
- Jaime Toro, MD
- Neurology
Pridopidine had no effect on the primary outcome but improved some motor functions in a manufacturer-funded, phase-III trial.- Reviewing:
- Garcia de Yebenes J et al., Lancet Neurol 2011 Dec; 10:1049.
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Phase II Trial of Latrepirdine in Huntington Disease
- April 13, 2010
- Yvette M. Bordelon, MD, PhD
- Neurology
Latrepirdine (Dimebon) was well tolerated and improved Mini-Mental State Examination scores in a short-term trial in patients with Huntington disease.- Reviewing:
- Kieburtz K et al., Arch Neurol 2010 Feb; 67:154.
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Does CAG Repeat Length Affect Clinical Progression in Huntington Disease?
- June 8, 2006
- Jang-Ho Cha, MD, PhD
- Neurology
Evidence from a large retrospective study suggests that CAG trinucleotide repeat length has a subtle effect on rate of progression.- Reviewing:
- Rosenblatt A et al., Neurology 2006 Apr 11; 66:1016-20.
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Imaging Inflammation in the Huntington Disease Brain
- October 23, 2007
- Jang-Ho Cha, MD, PhD
- Neurology
PET imaging identifies microglial activation, a marker of inflammation, in the brains of people with presymptomatic Huntington disease.- Reviewing:
- Tai YF et al., Brain 2007 Jul; 130:1759.
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Neuroprotective Role of Cannabinoid Mechanisms
- January 26, 2010
- Leslie L. Iversen, PhD
- Neurology
Cannabinoid CB2-receptor levels are increased in patients with Huntington disease, and they may play a neuroprotective role.- Reviewing:
- Palazuelos J et al., Brain 2009 Nov; 132:3152.
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Huntington's Disease: To Know or Not to Know?
- March 8, 2001
- JF Gusella
- Neurology
Predictive testing for Huntington's disease (HD) in at-risk offspring of affected individuals became available in the mid-1980s. The procedure -- linkage analysis with polymorphic DNA . . .- Reviewing:
- Maat-Kievit A et al., J Neurol Neurosurg Psychiatry 2000 Nov; 69:
579 583 .
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Treatable Dementias Mistaken for CJD
- November 22, 2011
- Michael D. Geschwind, MD, PhD
- Neurology
A retrospective analysis finds that many cases of treatable dementias may be misdiagnosed as sporadic Creutzfeldt-Jakob disease.- Reviewing:
- Chitravas N et al., Ann Neurol 2011 Sep; 70:437.
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Lithium’s Effect on Gray Matter
- March 4, 2008
- Jang-Ho Cha, MD, PhD
- Neurology
A volumetric MRI study indicates that lithium’s beneficial effects in bipolar patients may be due to an increase in gray matter.- Reviewing:
- Bearden CE et al., Biol Psychiatry 2007 Jul 1; 62:7. Chuang D-M and Manji HK., Biol Psychiatry 2007 Jul 1; 62:4.
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Smell Loss in the Ataxias -- A Cerebellar Disorder?
- January 16, 2004
- Christopher Hawkes, MD, FRCP
- Neurology
These two studies were prompted by recent evidence that the cerebellum, apart from its claimed role in language, may be involved in olfactory perception and . . .- Reviewing:
- Fernandez-Ruiz J et al., NeuroReport 2003 Jul 18; 14:1339-41. Connelly T et al., J Neurol Neurosurg Psychiatry 2003 Oct; 74:1435-7.
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Current Understanding of Mitochondrial Respiratory-Chain Diseases
- October 10, 2003
- Anthony H. V. Schapira, MD, DSc, FRCP
- Neurology
Mitochondrial disorders reflect the ubiquity of mitochondria by encompassing a huge array of diseases spanning virtually every specialty in medicine. DiMauro and Schon provide an . . .- Reviewing:
- DiMauro S and Schon EA., N Engl J Med 2003 Jun 26; 348:2656-68.
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Implications of Genetic Advances in Alzheimer's and Parkinson Disease
- July 11, 2003
- Stefan M. Pulst, MD
- Neurology
Nussbaum and Ellis review advances in understanding the genetic aspects of Alzheimer's disease (AD) and Parkinson disease (PD), two seemingly disparate diseases that share complex . . .- Reviewing:
- Nussbaum RL and Ellis CE., N Engl J Med 2003 Apr 3; 348:1356-64.
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Minocycline: A Novel Therapeutic Agent for Perinatal Ischemia?
- September 26, 2002
- Robert M. Friedlander, MD
- Neurology
Perinatal ischemic injury is a significant societal problem. Resulting neurologic deficits range from mild to devastating and fatal. These researchers evaluated the potential neuroprotective effect . . .- Reviewing:
- Arvin KL et al., Ann Neurol 2002 Jul; 52:54-61.
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What Is the True Prevalence of Early-Onset Frontotemporal Dementia?
- August 22, 2002
- Bruce L. Miller, MD
- Neurology
Recent research suggests that frontotemporal dementia (FTD) can be diagnosed during life and can be differentiated reliably from Alzheimer's disease (AD). Similarly, new research criteria . . .- Reviewing:
- Ratnavalli E et al., Neurology 2002 Jun 11; 58:1615-21.
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New Evidence for Genetic Contribution to Parkinson's Disease
- May 10, 2002
- Joseph H. Friedman, MD
- Neurology
Although some degree of familial aggregation of Parkinson's disease (PD) has been recognized for more than a century, the disease was until recently considered a . . .- Reviewing:
- Nicholl DJ et al., Brain 2002 Jan; 125:44-57.
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Is Creatine Protective in Neurodegenerative Disease?
- July 26, 2001
- DK Simon
- Neurology
Mitochondrial dysfunction and oxidative stress are thought to have roles in aging and in neurodegenerative diseases such as Huntington's disease (HD), Parkinson's disease (PD), and . . .- Reviewing:
- Tarnopolsky MA and Beal MF., Ann Neurol 2001 May; 49:
561 574 .
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Subcellular Distribution of Mutant Ataxin-2 Discovered
- June 1, 1999
- H Zoghbi
- Neurology
Eight neurodegenerative diseases result from the expansion of a CAG repeat coding for polyglutamine tracts in the respective proteins: the spinocerebellar ataxias (SCA) types 1 . . .- Reviewing:
- Huynh DP et al., Ann Neurol 1999 Feb; 45:
232 241 .
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Glucose Metabolism and Hippocampal Neuronal Density Uncorrelated in MTLE
- June 1, 1999
- JC Mazziotta
- Neurology
Although interictal PET scan reveals reduced glucose metabolism in 60% to 80% of patients with mesial temporal lobe epilepsy (MTLE), correlation of this finding with . . .- Reviewing:
- Foldvary N et al., Epilepsia 1999 Jan; 40:
26 29 .
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