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Search for Parkinson's Disease in Neurology
Physician-authored summaries on the latest research on Parkinson's disease, editorials on Parkinson's disease, and perspectives on Parkinson's disease - drawn from the top medical journals.
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You searched for: Parkinson's disease in Neurology
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Motor Restlessness in Parkinson Disease
- April 17, 2012
- Brian J. Murray, MD, FRCPC D, ABSM
- Neurology
A comparison of unmedicated patients with Parkinson disease and controls showed a nearly three times increased prevalence of leg motor restlessness but not typical restless legs syndrome.- Reviewing:
- Gjerstad MD et al., Neurology 2011 Nov 29; 77:1941.
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Does Lowering Cholesterol Reduce Parkinson Disease Risk?
- April 3, 2012
- Michael S. Okun, MD
- Neurology
An analysis of two large prospective cohorts suggests it might, but cautious interpretation is warranted.- Reviewing:
- Gao X et al., Arch Neurol 2012 Mar; 69:380.
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“On” Freezing in Parkinson Disease
- March 6, 2012
- Michael S. Okun, MD
- Neurology
What to do when dopamine replacement makes your patients with PD freeze.- Reviewing:
- Espay AJ et al., Neurology 2012 Feb 14; 78:454.
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Tai Chi vs. Other Exercises for Parkinson Disease
- February 8, 2012
- Michael S. Okun, MD
- Neurology
A randomized comparison suggests potential benefits from both tai chi and resistance training.- Reviewing:
- Li F et al., N Engl J Med 2012 Feb 9; 366:511.
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Are We Getting Closer to Blood Tests for Parkinson Disease?
- January 24, 2012
- Michael S. Okun, MD
- Neurology
A pilot study suggests so, despite methodologic issues.- Reviewing:
- Foulds PG et al., FASEB J 2011 Dec; 25:4127.
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Gene Therapy for Parkinson Disease: Where Do We Stand?
- May 24, 2011
- Michael Hutchinson, MD
- Neurology
Insertion of the glutamic acid decarboxylase gene into the subthalamic nuclei resulted in significant motor improvement compared with sham surgery.- Reviewing:
- LeWitt PA et al., Lancet Neurol 2011 Apr; 10:309.
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Novel Genetic Associations with Parkinson Disease
- April 26, 2011
- Clemens R. Scherzer, MD
- Neurology
A meta-analysis and replication of several genome-wide association studies confirms previous loci associated with PD and identifies several new ones.- Reviewing:
- International Parkinson Disease Genomics Consortium., Lancet 2011 Feb 19; 377:641.
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Does Adjunctive Preladenant Reduce “Off” Time in Parkinson Disease? Free
- April 19, 2011
- Graham Glass, MD
- Neurology
Phase II, dose-finding trial results suggest a modest reduction in “off” time, with acceptable safety.- Reviewing:
- Hauser RA et al., Lancet Neurol 2011 Mar; 10:221.
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Can Ibuprofen Reduce Parkinson Disease Risk?
- March 22, 2011
- David A. Grimes, MD, FRCPC
- Neurology
Data from two large questionnaire studies suggest a link, but whether it is causal remains unknown.- Reviewing:
- Gao X et al., Neurology 2011 Mar 8; 76:863. Bower JH and Ritz B., Neurology 2011 Mar 8; 76:854.
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Memantine for Parkinson Disease Dementia and Lewy Body Dementia
- October 19, 2010
- Andrew Siderowf, MD
- Neurology
A randomized trial shows a marginal benefit for LBD and has no effect for PDD.- Reviewing:
- Emre M et al., Lancet Neurol 2010 Oct; 9:969.
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Does Continuous Dopaminergic Stimulation Reduce Dyskinesia Risk?
- October 5, 2010
- Shyamal Mehta, MD, PhD
- Neurology
The STRIDE-PD trial was a good idea with a not-so-great design, and it leaves this question unanswered.- Reviewing:
- Stocchi F et al., Ann Neurol 2010 Jul; 68:18.
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What Causes Fatigue in Parkinson Disease?
- October 5, 2010
- Thomas D. Sabin, MD
- Neurology
A review of the evidence falls short of providing an answer.- Reviewing:
- Beiske AG and Svensson E., Acta Neurol Scand 2010 Jul; 122:78.
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Nonmotor Symptoms in Parkinson Disease
- September 28, 2010
- Christopher H. Hawkes, MD, FRCP
- Neurology
A review of the research on pathology and clinical findings- Reviewing:
- Tysnes O-B et al., Acta Neurol Scand 2010 Jul; 122:72.
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Pramipexole for Depression in Parkinson Disease
- June 29, 2010
- Joseph H. Friedman, MD
- Neurology
The largest study of depression in PD to date demonstrates that pramipexole is a statistically better treatment than placebo, but not by a lot.- Reviewing:
- Barone P et al., Lancet Neurol 2010 Jun; 9:573.
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Parkinson Disease and Anticholinergics Don't Mix Well
- May 18, 2010
- David A. Drachman, MD
- Neurology
Watch out for drugs with anticholinergic effects in your patients with PD.- Reviewing:
- Ehrt U et al., J Neurol Neurosurg Psychiatry 2010 Feb; 81:160. Starkstein SE., J Neurol Neurosurg Psychiatry 2010 Feb; 81:129.
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Depression and Parkinson Disease
- March 9, 2010
- Edison Miyawaki, MD
- Neurology
Of one practitioner's patients, 72% developed depression within 10 years of first parkinsonian symptoms.- Reviewing:
- Jasinska-Myga B et al., Can J Neurol Sci 2010 Jan; 37:61.
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Incidence and Risk for Dementia in Parkinson Disease
- March 2, 2010
- Joshua M. Shulman, MD, PhD
- Neurology
Findings from a prospective study confirm that dementia is common in Parkinson disease and suggest that two genes have divergent effects.- Reviewing:
- Williams-Gray CH et al., Brain 2009 Nov; 132:2958.
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ADAGIO/Rasagiline Study: Has Neuroprotection Been Achieved?
- November 17, 2009
- Lewis Sudarsky, MD
- Neurology
The study, along with previous research, supports a beneficial effect of MAO-B inhibitors on progression of motor disability, if not on the neurobiology of Parkinson disease.- Reviewing:
- Olanow CW et al., N Engl J Med 2009 Sep 24; 361:1268.
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Insufficient Evidence: A Retrial for a Suspected Parkinson Gene
- September 1, 2009
- Craig Blackstone, MD, PhD
- Neurology
A study fails to validate the association of GIGYF2 with Parkinson disease, highlighting the need for caution in using newly identified genes in genetic testing.- Reviewing:
- Nichols WC et al., Neurology 2009 Jun 2; 72:1886. Clark LN., Neurology 2009 Jun 2; 72:1882.
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Levodopa-Induced Dyskinesias
- July 21, 2009
- Joseph Jankovic, MD
- Neurology
A PET study supports presynaptic involvement.- Reviewing:
- Troiano AR et al., Neurology 2009 Apr 7; 72:1211. Vingerhoets FJG., Neurology 2009 Apr 7; 72:1202.
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