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Search for Multiple Sclerosis in Neurology
Physician-authored summaries on the latest research on multiple sclerosis, editorials on multiple sclerosis, and perspectives on multiple sclerosis - drawn from the top medical journals.
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You searched for: multiple sclerosis in Neurology
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Using Adult Criteria to Diagnose Pediatric MS Free
- April 10, 2012
- Robert T. Naismith, MD
- Neurology
The 2010 McDonald criteria for multiple sclerosis can be used in children older than 10 who do not present with acute disseminated encephalomyelitis.- Reviewing:
- Sadaka Y et al., Ann Neurol 2012 Mar 4;:
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Oral Laquinimod Demonstrates Efficacy in Relapsing MS
- March 14, 2012
- Robert T. Naismith, MD
- Neurology
A phase III trial demonstrated a modestly lower relapse rate and fewer imaging lesions compared with placebo, along with a more-substantial reduction in disability progression.- Reviewing:
- Comi G et al., N Engl J Med 2012 Mar 15; 366:1000.
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Firategrast Demonstrates Efficacy in Relapsing MS
- February 7, 2012
- Robert T. Naismith, MD
- Neurology
A phase II trial demonstrated reduction in enhancing magnetic resonance imaging lesions in patients with multiple sclerosis.- Reviewing:
- Miller DH et al., Lancet Neurol 2012 Feb; 11:131.
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Improvement in Visual Function with Stem-Cell Therapy in Progressive MS
- February 7, 2012
- Robert T. Naismith, MD
- Neurology
A small, open-label, proof-of-concept study suggests clinical and electrophysiological benefits.- Reviewing:
- Connick P et al., Lancet Neurol 2012 Feb; 11:150.
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Gene for Vitamin D Metabolism Implicated in Multiple Sclerosis Free
- January 17, 2012
- Robert T. Naismith, MD
- Neurology
Mutations that lead to altered vitamin D activation are identified as rare variants in familial MS.- Reviewing:
- Ramagopalan SV et al., Ann Neurol 2011 Dec; 70:881.
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What Dosage of Subcutaneous Interferon Beta-1a Is Best for Clinically Isolated Syndrome?
- January 3, 2012
- Robert T. Naismith, MD
- Neurology
Both weekly and thrice-weekly dosing was effective for patients with a first demyelinating event.- Reviewing:
- Comi G et al., Lancet Neurol 2012 Jan; 11:33.
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Gray-Matter Lesions and Inflammation in MS
- December 7, 2011
- Robert T. Naismith, MD
- Neurology
MS cortical lesions can be inflammatory in nature, not just a result of neurodegeneration, new biopsy evidence shows.- Reviewing:
- Lucchinetti CF et al., N Engl J Med 2011 Dec 8; 365:2188.
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Early vs. Delayed Initiation of Treatment Following a Clinically Isolated Syndrome Free
- November 29, 2011
- Jeffrey M. Gelfand, MD
- Neurology
Ten-year follow-up of the CHAMPS cohort suggests a reduction in conversion to clinically definite MS with early initiation of disease-modifying therapy.- Reviewing:
- Kinkel RP et al., Arch Neurol 2011 Oct 10;:
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Distinguishing MS from Acquired Demyelinating Syndrome in Children
- November 29, 2011
- Robert T. Naismith, MD
- Neurology
A diagnosis of pediatric multiple sclerosis is associated with a T1 hypointense lesion and a T2 periventricular lesion on baseline MRI.- Reviewing:
- Verhey LH et al., Lancet Neurol 2011 Dec; 10:1065.
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Ocrelizumab Demonstrates Efficacy in Relapsing MS
- November 15, 2011
- Robert T. Naismith, MD
- Neurology
A phase II trial demonstrated impressive results in reducing magnetic resonance imaging lesions and clinical relapses in patients with multiple sclerosis.- Reviewing:
- Kappos L et al., Lancet 2011 Nov 1;: Chataway J and Miller DH., Lancet 2011 Nov 1;:
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Teriflunomide Demonstrates Efficacy in Relapsing MS
- October 5, 2011
- Robert T. Naismith, MD
- Neurology
A phase III trial of this oral therapy for multiple sclerosis showed that it reduced relapses, disability, and new lesions on magnetic resonance imaging.- Reviewing:
- O'Connor P et al., N Engl J Med 2011 Oct 6; 365:1293.
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Meningeal B-Cell Follicles in MS
- October 4, 2011
- Robert T. Naismith, MD
- Neurology
A large autopsy study confirms an association between meningeal follicles, subpial demyelination, and severity of multiple sclerosis.- Reviewing:
- Howell OW et al., Brain 2011 Sep; 134:2755.
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Marijuana Extract for Spasticity in Multiple Sclerosis?
- October 4, 2011
- Robert T. Naismith, MD
- Neurology
A withdrawal trial does not provide evidence to support maintenance of benefit from nabiximols for spasticity.- Reviewing:
- Notcutt W et al., Mult Scler 2011 Aug 30;:
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Good Delivery Outcomes for Expectant Mothers with Multiple Sclerosis Free
- August 16, 2011
- Robert T. Naismith, MD
- Neurology
A large, population-based cohort study found no increase in adverse neonatal and delivery outcomes.- Reviewing:
- van der Kop ML et al., Ann Neurol 2011 Jul; 70:41.
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Breast-Feeding Does Not Affect Relapse Risk in Mothers with Multiple Sclerosis
- July 12, 2011
- Robert T. Naismith, MD
- Neurology
MS relapse rates before and during pregnancy — not the decision to breast-feed — predicted the likelihood of postpartum relapses.- Reviewing:
- Portaccio E et al., Neurology 2011 Jul 12; 77:145.
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When Patients with Multiple Sclerosis Discontinue Natalizumab . . .
- June 21, 2011
- Jeffrey M. Gelfand, MD
- Neurology
Disease activity began to return after 3 months but did not exceed pretreatment baseline rates.- Reviewing:
- O'Connor PW et al., Neurology 2011 May 31; 76:1858.
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Extended TRANSFORMS Trial Shows Benefit of Fingolimod Through Second Year Free
- June 7, 2011
- Robert T. Naismith, MD
- Neurology
Patients with multiple sclerosis who continued to receive fingolimod, as well as those who switched from interferon, appeared to do well.- Reviewing:
- Khatri B et al., Lancet Neurol 2011 Jun; 10:520.
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Does Cannabis Impair Cognition in Patients with Multiple Sclerosis?
- June 7, 2011
- Nadia Solowij, PhD
- Neurology
Information-processing speed, executive function, and visuospatial perception were significantly worse among long-term cannabis users than among nonusers in a cross-sectional study of MS patients.- Reviewing:
- Honarmand K et al., Neurology 2011 Mar 29; 76:1153.
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Is Severe Stress Associated with the Development of Multiple Sclerosis?
- May 31, 2011
- Robert T. Naismith, MD
- Neurology
Nurses' Health Study data show no link between self-reported severe stress events and the initial development of MS.- Reviewing:
- Riise T et al., Neurology 2011 May 30; 76:1866.
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Donepezil Does Not Improve Memory in Patients with Multiple Sclerosis Free
- May 10, 2011
- Robert T. Naismith, MD
- Neurology
This large study by leading MS cognitive experts provides clear conclusions.- Reviewing:
- Krupp LB et al., Neurology 2011 Apr 26; 76:1500.
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