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Multiple Sclerosis
Physician-authored summaries on the latest research on multiple sclerosis, editorials on multiple sclerosis, and perspectives on multiple sclerosis - drawn from the top medical journals.
You searched for: multiple sclerosis Items 1 to 20 of 128 results
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Link Between IL7R Polymorphisms and MS Reaffirmed
- November 6, 2007
- Samia J. Khoury, MD
Although one single nucleotide polymorphism generally is associated with slightly increased multiple sclerosis risk, IL7R’s most common haplotype confers protection.- Covering:
- Gregory SG et al., Nat Genet 2007 Sep; 39:1083.
- Lundmark F et al., Nat Genet 2007 Sep; 39:1108.
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NMO-IgG: Differentiating Neuromyelitis Optica from Multiple Sclerosis
- January 30, 2007
- Dean M. Wingerchuk, MD, MSc, FRCP(C)
New findings confirm the strong association of NMO-IgG, a serum autoantibody that targets aquaporin-4, with longitudinally extensive spinal cord lesions and Asian optic-spinal multiple sclerosis/neuromyelitis optica.- Covering:
- Nakashima I et al., J Neurol Neurosurg Psychiatry 2006 Sep; 77:1073-5.
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Optic Neuritis: Implications and Treatment
- July 6, 2006
- Shirley Wray, MD, PhD
How likely is a first episode of painful optic neuritis to presage multiple sclerosis, and how should it be treated?- Covering:
- Balcer LJ., N Engl J Med 2006 Mar 23; 354:1273-80.
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Altering the Course of MS: Pessimism vs. Optimism
- January 26, 2006
- Hillel Panitch, MD
In a review article, Coles proposes that the efficacy of currently approved multiple sclerosis (MS) therapies has been overstated and that the available agents (interferon . . .- Covering:
- Coles A., Pract Neurol 2005 Oct; 5:278-87.
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Using CSF Findings to Distinguish MS from Other Chronic CNS Inflammatory Diseases
- December 29, 2005
- Patricia K. Coyle, MD
This article addresses how CSF findings can differentiate multiple sclerosis (MS) from four masqueraders: neuropsychiatric lupus erythematosus, neurosarcoidosis, neuro-Behçet disease, and Sjögren syndrome. The authors . . .- Covering:
- Reske D et al., Acta Neurol Scand 2005 Oct; 112:207-13.
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Smoking and MS Progression
- August 3, 2005
- Robert J. Fox, MD
Cigarette smoking has been associated with a dose-dependent, 40% to 80% increased risk for multiple sclerosis (MS). No studies have evaluated the effect of smoking . . .- Covering:
- Hernán MA et al., Brain 2005 Jun; 128:1461-5.
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Cognitive Deficits in Children with MS
- July 21, 2005
- Tanuja Chitnis, MD
Pediatric multiple sclerosis (MS) is an increasingly recognized clinical subgroup within the general MS population. In this cross-sectional study, researchers examined cognitive functions in 37 . . .- Covering:
- MacAllister WS et al., Neurology 2005 Apr 26; 64:1422-5.
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Special Clinical-Phenotype Features in African Americans with Multiple Sclerosis
- June 9, 2005
- Alastair Compston, PhD, FRCP
Despite the relatively low frequency of multiple sclerosis (MS) in African Americans, these authors retrospectively identified 375 cases and compared their clinical features with those . . .- Covering:
- Cree BAC et al., Neurology 2004 Dec 14; 63:2039-45.
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Update on Autologous Hematopoietic-Stem-Cell Transplantation for MS
- March 24, 2005
- Samia Khoury, MD
These researchers review the current state of knowledge on autologous hematopoietic-stem-cell transplantation (HSCT) for treating severe multiple sclerosis (MS), including the underlying rationale and experimental . . .- Covering:
- Blanco Y et al., Lancet Neurol 2005 Jan; 4:54-63.
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Interferon-β Therapy for Secondary Progressive Multiple Sclerosis
- February 11, 2005
- Robert J. Fox, MD
Interferon-β (IFNβ) therapies have demonstrated a clear benefit in treating relapsing remitting multiple sclerosis (RRMS), but their benefit in secondary progressive MS (SPMS) is less . . .- Covering:
- Panitch H et al. for the North American Study Group on Interferon beta-1b in Secondary Progressive MS., Neurology 2004 Nov 23; 63:1788-95.
- Kappos L et al. for the EU-SPMS Trial Steering Committee and Independent Advisory Board and the NA-SPMS Trial Steering Committee and Independent Advisory Board., Neurology 2004 Nov 23; 63:1779-87.
- Cohen JA and Antel JP., Neurology 2004 Nov 23; 63:1768-9.
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Common Infections Late in Childhood Not Linked to Subsequent MS
- January 14, 2005
- Stuart D. Cook, MD
Multiple sclerosis (MS) is an immune-mediated disorder that occurs in genetically susceptible individuals following as-yet-unclear environmental exposures. Evidence for an infectious trigger of MS is . . .- Covering:
- Bager P et al., Brain 2004 Nov; 127:2491-7.
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Is Cannabis a Useful Treatment for Multiple Sclerosis Symptoms?
- January 16, 2004
- Leslie L. Iversen, PhD
Few controlled clinical trials have been done to support the use of cannabis for treating the symptoms of multiple sclerosis (MS). This multicenter, landmark study . . .- Covering:
- Zajicek J et al., Lancet 2003 Nov 8; 362:1517-26.
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Treatment for Depression Helps Fatigue in Multiple Sclerosis
- November 7, 2003
- Joel Yager, MD
About 90% of the roughly 350,000 Americans suffering from multiple sclerosis (MS) have reported severe debilitating fatigue, and it has been estimated that more than . . .- Covering:
- Mohr DC et al., Psychosom Med 2003 Jul/Aug; 65:542-7.
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Multiple Sclerosis: A Two-Stage Disease?
- March 27, 2003
- Richard A. Rudick, MD
Studies have shown that early clinical features of multiple sclerosis (MS) are predictive of subsequent disease progression. These investigators used a database of 1844 MS . . .- Covering:
- Confavreux C et al., Brain 2003 Apr; 126:770-82.
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Natalizumab Shows Promise for Treating Multiple Sclerosis
- February 7, 2003
- Michael J. Olek, DO
A multicenter, double-blind, randomized, manufacturer-sponsored study of intravenous natalizumab was conducted on 213 patients with relapsing-remitting or relapsing secondary multiple sclerosis (MS). Natalizumab, a humanized . . .- Covering:
- Miller DH et al. for the International Natalizumab Multiple Sclerosis Trial group., N Engl J Med 2003 Jan 2; 348:15-23.
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Characterizing Pure Opticospinal Multiple Sclerosis
- January 10, 2003
- Jun-ichi Kira, MD, PhD
In opticospinal multiple sclerosis (OSMS), a distinct demyelinating disease, the optic nerve and spinal cord are selectively involved, with usually minor brainstem signs in rare . . .- Covering:
- Misu T et al., Brain 2002 Nov; 125:2460-8.
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Is There Evidence for Sexual Transmission of Multiple Sclerosis?
- December 27, 2002
- Charles M. Poser, MD, FRCP
This author reviews evidence that he claims favors a sexually transmitted etiology for multiple sclerosis (MS). Evidence cited includes the unequal geographic and sexual (female-preponderant) . . .- Covering:
- Hawkes CH., J Neurol Neurosurg Psychiatry 2002 Oct; 73:439-43.
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Chlamydia and Multiple Sclerosis: Is There an Association?
- August 9, 2001
- DC Hess
The role of Chlamydia pneumoniae in the etiology of multiple sclerosis (MS) is controversial. To further explore this association, the reactivity of the oligoclonal antibody . . .- Covering:
- Yao SY et al., Neurology 2001 May; 56:
1168 1176 .
- Yao SY et al., Neurology 2001 May; 56:
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Acute Disseminated Encephalomyelitis vs. Multiple Sclerosis in Children
- April 12, 2001
- RS Rust
Postinfectious inflammatory CNS illnesses, such as acute disseminated encephalomyelitis (ADEM), are more common than multiple sclerosis (MS) in children. Typically monophasic, the boundaries between these . . .- Covering:
- Dale RC et al., Brain 2000 Dec; 123:
2407 2422 .
- Dale RC et al., Brain 2000 Dec; 123:
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Relapse, Remission, and Disability Progression in Multiple Sclerosis
- February 8, 2001
- RA Rudick
Many patients with multiple sclerosis (MS) develop progressive neurologic deterioration, but the relation between acute relapses and disability progression is unknown. Using a large database . . .- Covering:
- Confavreux C et al., N Engl J Med 2000 Nov 16; 343:
1430 1438 . - McDonald WI., N Engl J Med 2000 Nov 16; 343:
1486 1487 .
- Confavreux C et al., N Engl J Med 2000 Nov 16; 343:
You searched for: multiple sclerosis Items 1 to 20 of 128 results