Gene Therapy for Diabetic Neuropathy
SUMMARY AND COMMENT
June 9, 2009
Allan H. Ropper, MD, FRCP
Tentative evidence of the effectiveness of gene therapy with erythropoietin in an extensively studied animal model of diabetic neuropathy
Reviewing:
Chattopadhyay M et al., Brain 2009 Apr; 132:879
A Longitudinal Study of Insomnia
SUMMARY AND COMMENT
June 9, 2009
Paul T. Gross, MD
Insomnia is often persistent, and although remissions occur, relapses are also common.
Reviewing:
Morin CM et al., Arch Intern Med 2009 Mar 9; 169:447
Riluzole Does Not Prolong Survival in Progressive Supranuclear Palsy and Multisystem Atrophy
SUMMARY AND COMMENT
June 2, 2009
Amy Colcher, MD
But a clinical trial provides useful methodology for future studies of rapidly progressive neurodegenerative diseases.
Reviewing:
Bensimon G et al., Brain 2009 Jan; 132:156
Mitoxantrone plus Glatiramer Acetate for MS
SUMMARY AND COMMENT
June 2, 2009
Jacqueline Palace, BM, DM, FRCP
The combination reduced MRI markers of disease progression more than glatiramer alone.
Reviewing:
Arnold DL et al., J Neurol 2008 Oct; 255:1473
New Details on Camptocormia in Parkinson Disease
SUMMARY AND COMMENT
June 2, 2009
Talene Yacoubian, MD, PhD
A study of prevalence and associated factors
Reviewing:
Tiple D et al., J Neurol Neurosurg Psychiatry 2009 Feb; 80:145
Stiff-Person Syndrome with Anti-Amphiphysin Antibodies
SUMMARY AND COMMENT
June 2, 2009
Steven A. Greenberg, MD
A large study of patients with stiff-person syndrome refines the clinical features of patients with anti-amphiphysin antibodies, highlighting the very high frequency of breast cancer.
Reviewing:
Murinson BB and Guarnaccia JB., Neurology 2008 Dec 9; 71:1955
Genetic Observations in Restless Legs Syndrome
SUMMARY AND COMMENT
June 2, 2009
Brian J. Murray, MD, FRCPC(C) D, ABSM
A careful clinical and genetic assessment of a kindred of restless legs syndrome patients suggests the presence of a novel genetic mutation in a new gene locus.
Reviewing:
Young JE et al., Mayo Clin Proc 2009 Feb; 84:134
A New Focus of Creutzfeldt-Jakob Disease?
SUMMARY AND COMMENT
June 2, 2009
Amos D. Korczyn, MD, MSc
Is a cluster identified in Australia a result of heightened surveillance?
Reviewing:
Klug GM et al., Brain 2009 Feb; 132:493
Management of Medication Overuse Headache
SUMMARY AND COMMENT
June 2, 2009
Joel R. Saper, MD
Is withdrawal of acute medications necessary before prophylactic treatment is initiated?
Reviewing:
Hagen K et al., Cephalalgia 2009 Feb; 29:221
Mood Disorders, Epilepsy, and Surgery: Full Circle
SUMMARY AND COMMENT
June 2, 2009
Susan S. Spencer, MD
Lifetime history of psychiatric disorder predicts worse outcome after mesial temporal lobe resection, suggesting that an underlying disorder predisposes to both.
Reviewing:
Kanner AM et al., Neurology 2009 Mar 3; 72:793
